Thiol-reactive (co)polymer scaffolds comprising organic arsenical acrylamides,Chemical Communications

当前位置： X-MOL 学术 › Chem. Commun. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Thiol-reactive (co)polymer scaffolds comprising organic arsenical acrylamides
Chemical Communications ( IF 4.3 ) Pub Date : 2017-07-06 00:00:00 , DOI: 10.1039/c7cc03880a
Charlotte Footman _{1,

2,

3,

4} , Patrick A. J. M. de Jongh _{1,

2,

3,

4} , Joji Tanaka _{1,

2,

3,

4} , Raoul Peltier _{1,

2,

3,

4} , Kristian Kempe _{1,

2,

3,

4,

5} , Thomas P. Davis _{1,

2,

3,

4,

5} , Paul Wilson _{1,

2,

3,

4,

5}

Affiliation

Novel, well-defined organic arsenical homopolymers (Đ = 1.10–1.40) have been synthesised via RAFT polymerisation. Copolymerisation of the As-functional monomer with dimethylacrylamide yielded non-toxic polymer scaffolds (Đ ≈ 1.10) that could be manipulated in response to pH and undergo sequential reduction and substitution in the presence of thiols including cysteine and glutathione.

中文翻译：

包含有机砷丙烯酰胺的硫醇反应性（共）聚合物支架

通过RAFT聚合合成了新颖的，定义明确的有机砷均聚物（Đ = 1.10-1.40）。As-官能单体与二甲基丙烯酰胺的共聚反应可产生无毒的聚合物支架（Đ≈1.10），该支架可响应pH值进行操作，并在包括半胱氨酸和谷胱甘肽在内的硫醇存在下进行顺序还原和取代。

更新日期：2017-07-26

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11