Reductive Etherification via Anion-Binding Catalysis,Journal of the American Chemical Society

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Reductive Etherification via Anion-Binding Catalysis
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2017-07-25 , DOI: 10.1021/jacs.7b05832
Chenfei Zhao ₁ , Christopher A. Sojdak ₁ , Wazo Myint ₁ , Daniel Seidel ₁

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Reductive condensations of alcohols with aldehydes/ketones to generate ethers are catalyzed by a readily accessible thiourea organocatalyst that operates in combination with HCl. 1,1,3,3-tetramethyldisiloxane serves as a convenient reducing reagent. This strategy is applicable to challenging substrate combinations and exhibits functional group tolerance. Competing reductive homocoupling of the carbonyl component is suppressed.

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