Borapetoside E, a Clerodane Diterpenoid Extracted from Tinospora crispa, Improves Hyperglycemia and Hyperlipidemia in High-Fat-Diet-Induced Type 2 Diabetes Mice,Journal of Natural Products

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Borapetoside E, a Clerodane Diterpenoid Extracted from Tinospora crispa, Improves Hyperglycemia and Hyperlipidemia in High-Fat-Diet-Induced Type 2 Diabetes Mice
Journal of Natural Products ( IF 3.3 ) Pub Date : 2017-07-25 00:00:00 , DOI: 10.1021/acs.jnatprod.7b00365
Yuhui Xu _{1,

2} , Yanfen Niu _{1,

2,

3} , Yuan Gao _{4,

5} , Fang Wang _{1,

2} , Wanying Qin _{1,

2} , Yanting Lu _{1,

2} , Jing Hu _{1,

2} , Li Peng _{1,

2} , Jikai Liu ₆ , Wenyong Xiong _{1,

2}

Affiliation

An insidious increase in the incidence of obesity, insulin resistance, and hyperlipidemia has led to an epidemic of type 2 diabetes worldwide. Tinospora crispa (T. crispa) is a familiar plant traditionally used in herbal medicine for diabetes; however, the major active ingredients of this plant are still unclear. In this study, we identified the therapeutic effects of borapetoside E, a small molecule extracted from T. crispa, in high-fat-diet (HFD)-induced obesity in mice. The therapeutic effects of borapetoside E in HFD-induced obese mice were assessed physiologically, histologically, and biochemically following intraperitoneal injection. Furthermore, we analyzed the expression of glucose and lipid metabolism-related genes and proteins in borapetoside E-treated obese mice. Compared with vehicle-treated mice, borapetoside E markedly improved hyperglycemia, insulin resistance, hepatic steatosis, hyperlipidemia, and oxygen consumption in obese mice, and the effects were comparable to or better than the drug metformin. In addition, borapetoside E suppressed the expression of sterol regulatory element binding proteins (SREBPs) and their downstream target genes related to lipid synthesis in the liver and adipose tissue. Borapetoside E showed beneficial effects in vivo, demonstrating that borapetoside E may be a potential therapy for the treatment of diet-induced type 2 diabetes and related metabolic syndromes.

中文翻译：

Borapetoside E，一种从香茅（Tinospora crispa）提取的氯丹定双萜，可改善高脂饮食诱导的2型糖尿病小鼠的高血糖和高脂血症。

肥胖症，胰岛素抵抗和高脂血症的发生率急剧增加已导致全世界2型糖尿病的流行。Tinospora crispa（T. crispa）是一种熟悉的植物，传统上用于治疗糖尿病的草药；但是，该植物的主要活性成分仍不清楚。在这项研究中，我们发现borapetoside E的治疗效果，小分子摘自T.皱，是由高脂饮食（HFD）引起的小鼠肥胖引起的。腹膜内注射后，在生理，组织和生化方面评估了raprapetoside E在HFD诱导的肥胖小鼠中的治疗作用。此外，我们分析了在borapetoside E治疗的肥胖小鼠中葡萄糖和脂质代谢相关基因和蛋白质的表达。与赋形剂治疗的小鼠相比，波普拉托甙E显着改善了肥胖小鼠的高血糖症，胰岛素抵抗，肝脂肪变性，高脂血症和耗氧量，其效果与二甲双胍相当或更好。此外，波拉托甙E抑制了固醇调节元件结合蛋白（SREBPs）的表达及其与肝脏和脂肪组织中脂质合成有关的下游靶基因。菜籽糖苷E显示出有益的作用在体内，证明了波拉贝托E可能是治疗饮食引起的2型糖尿病和相关代谢综合征的潜在疗法。

更新日期：2017-07-25

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