Argonaute proteins constitute a highly diverse family of nucleic acid-guided proteins. They were first discovered in eukaryotes as key proteins in RNA interference systems, but homologous prokaryotic Argonaute proteins (pAgos) have also been found in archaea and bacteria. In this Progress article, we focus on long pAgo variants, a class of pAgos that are involved in nucleic acid-guided host defence against invading nucleic acids, and discuss the potential of pAgos in genome editing.

中文翻译：

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原核Argonaute蛋白：新型的基因组编辑工具？

Argonaute蛋白构成了核酸指导蛋白的高度多样化的家族。它们首先在真核生物中被发现为RNA干扰系统中的关键蛋白，但在古细菌和细菌中也发现了同源的原核Argonaute蛋白（pAgos）。在这篇“进展”文章中，我们重点介绍长的pAgo变体，这是一类参与核酸引导的宿主对入侵核酸的防御的pAgos，并讨论了pAgos在基因组编辑中的潜力。