Radiofluorination of a NHC–PF5 adduct: toward new probes for 18F PET imaging,Chemical Communications

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Radiofluorination of a NHC–PF5 adduct: toward new probes for 18F PET imaging
Chemical Communications ( IF 4.3 ) Pub Date : 2017-07-11 00:00:00 , DOI: 10.1039/c7cc04402j
Boris Vabre _{1,

2,

3,

4} , Kantapat Chansaenpak _{4,

5,

6,

7,

8} , Mengzhe Wang _{4,

5,

6,

7,

8} , Hui Wang _{4,

5,

6,

7,

8} , Zibo Li _{4,

5,

6,

7,

8} , François P. Gabbaï _{1,

2,

3,

4}

Affiliation

The radiofluorination of N-heterocyclic carbene (NHC) phosphorus(V) fluoride adducts has been investigated. The results show that the IMe-PF₅ derivative (IMe = 1,3-dimethylimidazol-2-ylidene) undergoes a Lewis acid promoted ¹⁸F–¹⁹F isotopic exchange. The resulting radiofluorinated probe is remarkably resistant to hydrolysis both in vitro as well as in vivo.

中文翻译：

NHC–PF ₅加合物的放射性氟化：朝向用于¹⁸ F PET成像的新探针

研究了N-杂环卡宾（NHC）磷（V）氟化物加合物的放射性氟化。结果表明，IMe-PF ₅衍生物（IMe = 1,3-二甲基咪唑-2-亚基）经历了路易斯酸促进的¹⁸ F– ¹⁹ F同位素交换。所得的放射性氟化探针在体外和体内均具有显着的抗水解能力。

更新日期：2017-07-22

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