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Copper-catalyzed Mannich-type oxidative β-functionalization of tertiary amines
Chemical Communications ( IF 4.9 ) Pub Date : 2017-07-10 00:00:00 , DOI: 10.1039/c7cc04761d Min-Jie Zhou 1, 2, 3, 4, 5 , Shou-Fei Zhu 1, 2, 3, 4, 5 , Qi-Lin Zhou 1, 2, 3, 4, 5
Chemical Communications ( IF 4.9 ) Pub Date : 2017-07-10 00:00:00 , DOI: 10.1039/c7cc04761d Min-Jie Zhou 1, 2, 3, 4, 5 , Shou-Fei Zhu 1, 2, 3, 4, 5 , Qi-Lin Zhou 1, 2, 3, 4, 5
Affiliation
A copper-catalyzed Mannich-type oxidative β-functionalization reaction of amines has been developed. In the presence of an oxidant and a copper catalyst, tertiary amines reacted with N-tosylimines, providing synthetically important 1,3-diamines and enamines, respectively. Preliminary mechanistic studies suggested that the oxidation of the tertiary amine to the enamine intermediate triggers subsequent Mannich-type reactions with N-tosylimines and thus enables the direct β-functionalization of the tertiary amines.
中文翻译:
铜催化叔胺的曼尼希型氧化β-官能化
已经开发了铜催化的胺的曼尼希型氧化β-官能化反应。在氧化剂和铜催化剂的存在下,叔胺与N-甲苯磺酰亚胺反应,分别提供了合成上重要的1,3-二胺和烯胺。初步的机理研究表明,叔胺氧化为烯胺中间体会触发随后的N-甲苯磺胺类曼尼希型反应,从而使叔胺直接进行β-官能化。
更新日期:2017-07-22
中文翻译:
铜催化叔胺的曼尼希型氧化β-官能化
已经开发了铜催化的胺的曼尼希型氧化β-官能化反应。在氧化剂和铜催化剂的存在下,叔胺与N-甲苯磺酰亚胺反应,分别提供了合成上重要的1,3-二胺和烯胺。初步的机理研究表明,叔胺氧化为烯胺中间体会触发随后的N-甲苯磺胺类曼尼希型反应,从而使叔胺直接进行β-官能化。