The spatial and temporal control of self-assemblies is the latest scientific hurdle in supramolecular chemistry which is inspired by the functioning of biological systems fueled by chemical signals. In this study, we work towards alleviating this scenario by employing a unique amphiphilic foldamer that operates under the effect of a chemical fuel. The conformational changes in the foldamer amplify into observable morphological changes in its amphiphilic assembly that are controlled by external molecular cues (fuel). We take advantage of this redox responsive foldamer to affect its conformation in a temporal manner by an enzymatic pathway. The temporal characteristics of the transient conformation/assembly can be modulated by varying the concentrations of the fuel and enzyme. We believe that such a design strategy can have positive consequences in designing molecular and supramolecular systems for future active, adaptive and autonomous materials.

中文翻译：

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通过化学燃料驱动的构象响应对两亲性自组装的时间转换

自组装的空间和时间控制是超分子化学的最新科学障碍，其灵感来自化学信号推动的生物系统的功能。在本研究中，我们致力于通过使用在化学燃料作用下运行的独特两亲性折叠剂来缓解这种情况。折叠器中的构象变化放大为两亲性装配中可观察到的形态变化，该变化由外部分子提示（燃料）控制。我们利用这种氧化还原反应性折叠剂通过酶促途径以时间方式影响其构象。瞬时构象/组装的时间特性可以通过改变燃料和酶的浓度来调节。