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Sam68 Offers Selectively Aimed Modulation of Transcription in Cancer Stem Cells
Cell Chemical Biology ( IF 8.6 ) Pub Date : 2017-07-20 , DOI: 10.1016/j.chembiol.2017.07.003
Kai Fu , Fengyi Wan

In this issue ofCell Chemical Biology,Benoit et al. (2017)report the selective targeting of cancer stem cells (CSCs) by the ICG-001/CWP family of molecules. Their findings reveal that Sam68 is a transcriptional modulator uniquely required for the dysregulated Wnt/β-catenin signaling in CSCs over healthy stem cells.

中文翻译:

Sam68在癌症干细胞中提供选择性的转录调控。

在本期《细胞化学生物学》中,Benoit等人。(2017)报告了ICG-001 / CWP分子家族对癌症干细胞(CSC)的选择性靶向。他们的发现表明,Sam68是转录因子,是健康干细胞中CSC中Wnt /β-catenin信号失调的唯一必需条件。
更新日期:2017-07-22
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