Aerobic Oxidation of Diverse Primary Alcohols to Carboxylic Acids with a Heterogeneous Pd–Bi–Te/C (PBT/C) Catalyst,Organic Process Research & Development

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Aerobic Oxidation of Diverse Primary Alcohols to Carboxylic Acids with a Heterogeneous Pd–Bi–Te/C (PBT/C) Catalyst
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2017-07-21 00:00:00 , DOI: 10.1021/acs.oprd.7b00223
Maaz S. Ahmed ₁ , David S. Mannel ₁ , Thatcher W. Root ₁ , Shannon S. Stahl ₁

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Heterogeneous catalytic aerobic oxidation methods represent a near-ideal approach for the conversion of primary alcohols to carboxylic acids. Here, we report that a heterogeneous catalyst composed of Pd, Bi, and Te supported on activated carbon is highly effective for the oxidation of diverse benzylic and aliphatic primary alcohols, including 5-(hydroxymethyl)furfural (HMF) and substrates bearing heterocycles and other important functional groups. In many cases, the desired carboxylic acid product is obtained in >90% yield. Additionally, the catalyst has been demonstrated in a continuous-flow packed-bed reactor for the oxidation of benzyl alcohol, achieving near-quantitative yield while undergoing over 30 000 turnovers.

中文翻译：

多相Pd-Bi-Te / C（PBT / C）催化剂将多种伯醇有氧氧化为羧酸

异构催化好氧氧化方法代表了将伯醇转化为羧酸的近乎理想的方法。在这里，我们报告说，由载于活性炭上的Pd，Bi和Te组成的多相催化剂对于多种苄基和脂肪族伯醇的氧化非常有效，包括5-（羟甲基）糠醛（HMF）和带有杂环和其他底物的底物重要的功能组。在许多情况下，以> 90％的收率获得了所需的羧酸产物。另外，已经在连续流式填充床反应器中证明了该催化剂用于苯甲醇的氧化，实现了近定量的收率，同时进行了超过3万次周转。

更新日期：2017-07-22

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