It is known that dendrimers can bind proteins with good selectively. This selectivity comes about from an optimization based on matching the size of the dendrimer with the size of the protein’s interfacial binding area. In this paper, we report how this selectivity can be moderated by the functionality on the surface of the dendrimer. Specifically, we describe the synthesis of amino acid functionalized dendrimers and the effect of functionality on the dendrimer’s ability to bind and inhibit the enzymatic protein, chymotrypsin. The results show how dendrimer binding can be increased or decreased depending on the terminal functionality. These results will allow new ligands to be designed and synthesized, possessing increased and selective protein-binding abilities.

中文翻译：

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末端基团功能对树枝状聚合物结合蛋白能力的影响

已知树状聚合物可以很好地选择性结合蛋白质。这种选择性来自基于树状大分子的大小与蛋白质界面结合区域大小的匹配的优化。在本文中，我们报告了如何通过树枝状聚合物表面的官能度来调节这种选择性。具体来说，我们描述了氨基酸功能化树状聚合物的合成以及功能对树状聚合物结合和抑制酶促蛋白胰凝乳蛋白酶的能力的影响。结果显示了如何根据末端官能度增加或减少树状聚合物的结合。这些结果将允许设计和合成具有增加的和选择性的蛋白质结合能力的新配体。