Novel affinity agents with high specificity are needed to make progress in disease diagnosis and therapy. Over the last several years, peptides have been considered to have fundamental benefits over other affinity agents, such as antibodies, due to their fast blood clearance, low immunogenicity, rapid tissue penetration, and reproducible chemical synthesis. These features make peptides ideal affinity agents for applications in disease diagnostics and therapeutics for a wide variety of afflictions. Virus-derived peptide techniques provide a rapid, robust, and high-throughput way to identify organism-targeting peptides with high affinity and selectivity. Here, we will review viral peptide display techniques, how these techniques have been utilized to select new organism-targeting peptides, and their numerous biomedical applications with an emphasis on targeted imaging, diagnosis, and therapeutic techniques. In the future, these virus-derived peptides may be used as common diagnosis and therapeutics tools in local clinics.

中文翻译：

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用于临床应用的病毒衍生肽

需要具有高特异性的新型亲和剂才能在疾病诊断和治疗方面取得进展。在过去的几年中，肽被认为比其他亲和剂（例如抗体）具有根本优势，因为它们具有快速血液清除、低免疫原性、快速组织渗透和可重复的化学合成。这些特性使肽成为疾病诊断和治疗多种疾病的理想亲和剂。病毒衍生肽技术提供了一种快速、稳健和高通量的方法来识别具有高亲和力和选择性的生物体靶向肽。在这里，我们将回顾病毒肽展示技术，如何利用这些技术来选择新的生物体靶向肽，以及它们的众多生物医学应用，重点是靶向成像、诊断和治疗技术。未来，这些病毒衍生肽可能会成为当地诊所常用的诊断和治疗工具。