Using Cooperatively Folded Peptides To Measure Interaction Energies and Conformational Propensities,Accounts of Chemical Research

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Using Cooperatively Folded Peptides To Measure Interaction Energies and Conformational Propensities
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2017-07-19 00:00:00 , DOI: 10.1021/acs.accounts.7b00195
Maziar S. Ardejani ₁ , Evan T. Powers ₁ , Jeffery W. Kelly _{1,

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Affiliation

The rates and equilibria of the folding of biopolymers are determined by the conformational preferences of the subunits that make up the sequence of the biopolymer and by the interactions that are formed in the folded state in aqueous solution. Because of the centrality of these processes to life, quantifying conformational propensities and interaction strengths is vitally important to understanding biology. In this Account, we describe our use of peptide model systems that fold cooperatively yet are small enough to be chemically synthesized to measure such quantities.

中文翻译：

使用合作折叠的肽段来测量相互作用能和构象倾向

生物聚合物折叠的速率和平衡性由构成生物聚合物序列的亚基的构象偏好以及在折叠状态下在水溶液中形成的相互作用决定。由于这些过程对于生命至关重要，因此量化构象倾向和相互作用强度对于理解生物学至关重要。在此帐户中，我们描述了我们使用的肽模型系统，该系统可以协同折叠，但体积很小，可以化学合成以测量此类数量。

更新日期：2017-07-19

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