Nowadays food safety has become one of the focus topics all over the world. Illegal addition of additives and chemical contaminants are the prominent problems. Because of the advantages of high resolution mass spectrometry (HRMS), the combination of liquid chromatography (LC) with HRMS has been more and more used in food safety analysis, but most of related analytical methods have been developed to detect the specific known compounds. For unknown harmful compounds in food, nontargeted screening method is a complementary one. However, there are still a lot of challenges in the nontargeted analysis. Here, the recent studies about sample preparation, LC-HRMS profiling analysis, data pretreatment, differential analysis, identification of unknown compounds in nontargeted screening of chemical contaminants and illegal additives in food are reviewed based on the papers published mainly in 2010-2017, which can be helpful for defining potential risk compounds in food analysis in the future.

中文翻译：

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基于液相色谱-高分辨率质谱的食品非目标化学污染物和非法添加剂筛选

如今，食品安全已成为全世界关注的主题之一。非法添加添加剂和化学污染物是突出的问题。由于高分辨率质谱法（HRMS）的优势，液相色谱法（LC）与HRMS的结合已越来越多地用于食品安全分析中，但是已开发出大多数相关分析方法来检测特定的已知化合物。对于食品中未知的有害化合物，非靶向筛选方法是一种补充方法。但是，非目标分析仍然存在很多挑战。在这里，有关样品制备，LC-HRMS分析，数据预处理，差异分析的最新研究