Enterovirus 71 (EV71) is a major causative agent of hand, foot, and mouth disease (HFMD), which can spread its infections to the central nervous and other systems with severe consequences. The viral caspid protein VP1 is a well-known target for antiviral efficacy because its occupancy by suitable compounds could stabilize the virus capsid, thus preventing uncoating of virus for RNA release. In this Letter, design, synthesis, and biological evaluation of novel anti-EV71 agents (aminopyridyl 1,2,5-thiadiazolidine 1,1-dioxides) are described. One of the most promising compounds (14) showed excellent antiviral activity against EV71 (EC₅₀ = 4 nM) and exhibited excellent in vivo efficacy in the EV71 infected mouse model.

中文翻译：

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发现用于治疗手足口病的有效EV71衣壳抑制剂

肠病毒71（EV71）是手足口病（HFMD）的主要病原体，可将其感染传播到中枢神经系统和其他系统，造成严重后果。病毒外壳蛋白VP1是抗病毒功效的众所周知的靶标，因为它被合适的化合物占据可以稳定病毒衣壳，从而防止病毒脱膜以释放RNA。在这封信中，描述了新型抗EV71药物（氨基吡啶基1,2,5-噻二唑烷1,1-二氧化物）的设计，合成和生物学评估。最有前途的化合物之一（14）对EV71表现出优异的抗病毒活性（EC ₅₀ = 4 nM），并且在被EV71感染的小鼠模型中表现出出色的体内功效。