A practical and efficient synthesis of the FLAP inhibitor 1 was developed addressing multiple scale-up and safety concerns posed by the established synthesis and utilized a resolution strategy (replacing supercritical fluid chromatography (SFC) separation) for expedient access to the key structural component of 1: the challenging chiral quaternary center. Also highlighted are in situ IR monitoring, condensation to form the 1,2,4-oxadiazole ring, and an efficient Suzuki-Miyaura coupling.

中文翻译：

---

结构具有挑战性的5-脂氧合酶激活蛋白（FLAP）抑制剂的早期发展规模。

开发了一种切实有效的FLAP抑制剂1合成方法，以解决已建立的合成方法所引起的多种放大和安全问题，并利用拆分策略（取代超临界流体色谱法（SFC）分离）方便地获得了1的关键结构成分：具有挑战性的手性四元中心。还强调了原位红外监测，缩合形成1,2,4-恶二唑环以及有效的Suzuki-Miyaura偶联。