Described herein is a novel concept for S_N2 reactions at tertiary carbon centers in epoxides without activation of the leaving group. Quantum chemical calculations show why S_N2 reactions at tertiary carbon centers are proceeding in these systems. The reaction allows flexible synthesis of 1,3-diol building blocks for natural product synthesis with excellent control of the relative and absolute configurations.

中文翻译：

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环氧化物中叔碳中心的SN2反应

本文描述了在环氧化物中叔碳中心处的S _N 2反应而不活化离去基团的新颖概念。量子化学计算表明为什么在这些系统中三级碳中心的S _N 2反应正在进行。该反应可灵活合成用于天然产物合成的1,3-二醇结构单元，并具有相对和绝对构型的出色控制。