Radical cascade cyclization of 1,n-enynes and diynes for the synthesis of carbocycles and heterocycles,Chemical Society Reviews

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Radical cascade cyclization of 1,n-enynes and diynes for the synthesis of carbocycles and heterocycles
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2017-06-06 00:00:00 , DOI: 10.1039/c6cs00912c
Jun Xuan _{1,

2,

3,

4} , Armido Studer _{5,

6,

7,

8}

Affiliation

Carbo- and heterocycles are widely found in natural products, biologically active structures, medicinally relevant compounds, and in many other fine chemicals. The development of novel, general and efficient methods for their construction has therefore gained great interest in synthetic organic chemistry. Recently, radical chemistry has become a heavily investigated research field (a renaissance!). Along these lines, radical cascade cyclization of 1,n-enynes and diynes has emerged as a powerful strategy for the preparation of carbo- and heterocycles. In this review, we highlight recent advances in this rapidly growing area also focusing on reaction mechanisms.

中文翻译：

1，n-烯和二炔的自由基级联环化反应，用于合成碳环和杂环

碳环和杂环广泛存在于天然产物，生物活性结构，医学上相关的化合物以及许多其他精细化学品中。因此，开发新颖，通用和有效的构建方法对合成有机化学引起了极大的兴趣。最近，自由基化学已成为一个受到广泛研究的研究领域（复兴！）。沿着这些思路，1，n-炔和二炔的自由基级联环化已经成为制备碳环和杂环的有力策略。在这篇综述中，我们着重介绍了这一快速增长领域中的最新进展，并且重点关注了反应机制。

更新日期：2017-07-18

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