Jumping Hurdles: Peptides Able To Overcome Biological Barriers,Accounts of Chemical Research

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Jumping Hurdles: Peptides Able To Overcome Biological Barriers
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2017-07-17 00:00:00 , DOI: 10.1021/acs.accounts.7b00204
Macarena Sánchez-Navarro ₁ , Meritxell Teixidó ₁ , Ernest Giralt _{1,

2}

Affiliation

The cell membrane, the gastrointestinal tract, and the blood–brain barrier (BBB) are good examples of biological barriers that define and protect cells and organs. They impose different levels of restriction, but they also share common features. For instance, they all display a high lipophilic character. For this reason, hydrophilic compounds, like peptides, proteins, or nucleic acids have long been considered as unable to bypass them. However, the discovery of cell-penetrating peptides (CPPs) opened a vast field of research. Nowadays, CPPs, homing peptides, and blood–brain barrier peptide shuttles (BBB-shuttles) are good examples of peptides able to target and to cross various biological barriers.

中文翻译：

跳跃的障碍：能够克服生物障碍的肽

细胞膜，胃肠道和血脑屏障（BBB）是定义和保护细胞和器官的生物屏障的很好例子。它们施加了不同级别的限制，但是它们也具有共同的特征。例如，它们都显示出高亲脂性。因此，长期以来，亲水性化合物（如肽，蛋白质或核酸）一直被认为无法绕过它们。然而，细胞穿透肽（CPPs）的发现打开了广阔的研究领域。如今，CPP，归巢肽和血脑屏障肽穿梭（BBB-穿梭）是能够靶向并穿越各种生物屏障的肽的良好实例。

更新日期：2017-07-17

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