Biocatalysis with Unnatural Amino Acids: Enzymology Meets Xenobiology,Angewandte Chemie International Edition

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Biocatalysis with Unnatural Amino Acids: Enzymology Meets Xenobiology
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2017-07-17 06:25:48 , DOI: 10.1002/anie.201610129
Federica Agostini _{1,

2} , Jan‐Stefan Völler ₁ , Beate Koksch ₂ , Carlos G. Acevedo‐Rocha ₃ , Vladimir Kubyshkin ₁ , Nediljko Budisa ₁

Affiliation

The goal of xenobiology is to design biological systems endowed with unusual biochemical functions, whereas enzymology concerns the study of enzymes, the workhorses of biocatalysis. Biocatalysis employs enzymes and organisms to perform useful biotransformations in synthetic chemistry and biotechnology. During the past few years, the effects of incorporating noncanonical amino acids (ncAAs) into enzymes with potential applications in biocatalysis have been increasingly investigated. In this Review, we provide an overview of the effects of new chemical functionalities that have been introduced into proteins to improve various facets of enzymatic catalysis. We also discuss future research avenues that will complement unnatural mutagenesis with standard protein engineering to produce novel and versatile biocatalysts with applications in synthetic organic chemistry and biotechnology.

中文翻译：

非天然氨基酸的生物催化：酶学与异物生物学

异种生物学的目标是设计具有异常生化功能的生物系统，而酶学则关注酶的研究，而酶是生物催化的主要手段。生物催化利用酶和生物体在合成化学和生物技术中进行有用的生物转化。在过去的几年中，越来越多地研究了将非规范氨基酸（ncAAs）掺入到酶中的潜在作用，并将其应用到生物催化中。在本综述中，我们概述了已引入蛋白质中以改善酶催化各个方面的新化学功能的作用。

更新日期：2017-07-17

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