Antibiotic resistance is one of the greatest current threats to human health, and without significant action we face the chilling prospect of a world without effective antibiotics. Although continued effort toward the development of new antibiotics, particularly those with novel mechanisms of action, remains crucial, this alone probably will not be enough to prevail, and it is imperative that additional approaches are also explored. One such approach is the identification of adjuvants that augment the activity of current antibiotics. This approach has the potential to render an antibiotic against which bacteria have developed resistance once again effective, to broaden the spectrum of an antibiotic, and to lower the required dose of an antibiotic. In this viewpoint we discuss some of the advantages and disadvantages of the use of adjuvants, and describe various approaches to their identification.

中文翻译：

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克服抗生素耐药性的挑战：辅助方法？

抗生素抗性是当前对人类健康的最大威胁之一，如果不采取重大行动，我们将面临一个没有有效抗生素的世界的严峻前景。尽管继续努力开发新抗生素，尤其是具有新作用机制的新抗生素，仍然很重要，但是仅凭这一点可能不足以占上风，因此必须探索其他方法。一种这样的方法是鉴定增加当前抗生素活性的佐剂。这种方法具有使产生针对其的细菌的抗性的抗生素再次有效，扩大抗生素的范围并降低所需剂量的抗生素的潜力。以这种观点，我们讨论了使用佐剂的一些优缺点，