In this issue of Cancer Cell, Qu et al. describe the chromatin accessibility profiles of cutaneous T cell lymphoma, with dynamic assessments of response and resistance to histone deacetylase inhibitor therapy. Their "personal regulome" analysis framework reveals chromatin features that may be predictive of clinical response to epigenetic therapy.

中文翻译：

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HDAC抑制剂终于揭开面纱：CTCL的染色质可及性签名。

在本期《癌细胞》中，Qu等人。描述了皮肤T细胞淋巴瘤的染色质可及性概况，并动态评估了对组蛋白脱乙酰基酶抑制剂治疗的反应和耐药性。他们的“个人调节”分析框架揭示了染色质特征，这些特征可以预测对表观遗传疗法的临床反应。