There has been a resurgence in interest in phenotypic drug discovery (PDD) approaches in recent years based on their potential to address the incompletely understood complexity of diseases and their promise of delivering first-in-class drugs. However, PDD approaches can also present considerable challenges, and this article focuses on the lessons learned by researchers engaged in PDD in the pharmaceutical industry, and discusses how PDD can best deliver value to drug discovery portfolios.

中文翻译：

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表型药物发现的机遇与挑战：行业观点

近年来，基于表型药物发现（PDD）方法的潜力正在重新兴起，因为它们具有解决尚未完全理解的疾病复杂性的潜力以及其提供一流药物的希望。但是，PDD方法也可能带来巨大挑战，本文重点介绍从事制药行业PDD的研究人员的经验教训，并讨论PDD如何才能最好地为药物开发投资组合创造价值。