Podocyte depletion drives kidney disease and kidney failure progression, but podocyte complexity at the glomerular filtration barrier is difficult to model in vitro. In Nature Biomedical Engineering, Musah et al. (2017) developed a multifluidic device with iPS-derived podocytes mimicking a functional glomerular filtration barrier that elevates standards for modeling glomerular diseases.

中文翻译：

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建模肾小球滤过屏障：您是在肾脏吗？

足细胞耗竭会驱动肾脏疾病和肾衰竭进展，但肾小球滤过屏障处的足细胞复杂性很难在体外建模。在《自然生物医学工程》中，Musah等人。（2017）用iPS衍生的足细胞开发了一种模仿功能性肾小球滤过屏障的多流体装置，该装置提高了建模肾小球疾病的标准。