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The Evolving Roles of Human iPSC-Derived Cardiomyocytes in Drug Safety and Discovery.
Cell Stem Cell ( IF 19.8 ) Pub Date : 2017-07-06 , DOI: 10.1016/j.stem.2017.06.005
Gary Gintant , Bernard Fermini , Norman Stockbridge , David Strauss

Nonclinical studies of drug effects with human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) provide new possibilities for evaluating drug safety and efficacy. The Comprehensive In Vitro Proarrhythmia Assay (CiPA) paradigm provides lessons from the cardiac field that also apply to drug studies with other stem cell-based assays.

中文翻译:

人iPSC衍生的心肌细胞在药物安全性和发现中的进化作用。

用人类诱导的多能干细胞衍生的心肌细胞(hiPSC-CM)进行药物作用的非临床研究为评估药物安全性和有效性提供了新的可能性。综合体外心律失常测定(CiPA)范例提供了心脏领域的经验教训,这些经验教训也适用于其他基于干细胞的测定的药物研究。
更新日期:2017-07-06
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