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Retinoic Acid Puts Hematopoietic Stem Cells Back To Sleep.
Cell Stem Cell ( IF 23.9 ) Pub Date : 2017-07-06 , DOI: 10.1016/j.stem.2017.06.002
Alexandra Rundberg Nilsson , Cornelis Jan Pronk

Dormant hematopoietic stem cells (dHSCs) display superior serial reconstitution capacity compared to active HSCs, although their role in normal hematopoiesis has not been thoroughly investigated. Recently in Cell, Cabezas-Wallscheid et al. (2017) demonstrate involvement of retinoic acid signaling in murine dHSCs for preservation of the HSC pool.

中文翻译:

维甲酸使造血干细胞重新进入睡眠状态。

休眠造血干细胞(dHSCs)与活跃的造血干细胞相比,显示出更好的系列重建能力,尽管尚未对它们在正常造血中的作用进行彻底研究。最近在Cell中,Cabbezas-Wallscheid等人。(2017)证明了维甲酸信号参与了小鼠dHSC的保存,以保护HSC库。
更新日期:2017-07-06
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