Cell-mediated drug-delivery systems have received considerable attention for their enhanced therapeutic specificity and efficacy in cancer treatment. Neutrophils (NEs), the most abundant type of immune cells, are known to penetrate inflamed brain tumours. Here we show that NEs carrying liposomes that contain paclitaxel (PTX) can penetrate the brain and suppress the recurrence of glioma in mice whose tumour has been resected surgically. Inflammatory factors released after tumour resection guide the movement of the NEs into the inflamed brain. The highly concentrated inflammatory signals in the brain trigger the release of liposomal PTX from the NEs, which allows delivery of PTX into the remaining invading tumour cells. We show that this NE-mediated delivery of drugs efficiently slows the recurrent growth of tumours, with significantly improved survival rates, but does not completely inhibit the regrowth of tumours.

中文翻译：

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中性粒细胞介导的抗癌药物抑制术后恶性神经胶质瘤复发

细胞介导的药物递送系统由于其在癌症治疗中增强的治疗特异性和功效而受到了广泛的关注。嗜中性粒细胞（NEs）是免疫细胞中最丰富的类型，已知会穿透发炎的脑肿瘤。在这里，我们显示携带含有紫杉醇（PTX）的脂质体的NE可以穿透大脑，并抑制肿瘤已被手术切除的小鼠的神经胶质瘤的复发。肿瘤切除后释放的炎性因子指导NEs进入发炎的大脑。脑中高度集中的炎性信号触发脂质体PTX从NE释放，从而使PTX可以传递到其余的侵袭性肿瘤细胞中。我们表明，这种由NE介导的药物递送有效地减缓了肿瘤的复发性生长，