Abstract Magnetic nanoparticle (MNP)-mediated heating systems have emerged as an effective strategy for the fine control of biological systems from hyperthermia to cell signaling in a spatiotemporally controlled fashion. To achieve satisfactory performance, advanced design concepts have been developed to tailor the magnetism that directly affects the heating properties of nanoparticles. In this review, we focus on recent advances in magnetism-engineered nanoparticles. Fundamental principles of magnetic heating mechanisms and related key magnetic parameters are discussed first to provide instructive guidelines for the design of MNPs with enhanced heating efficiency. Then, we highlight recent progress in MNPs for optimized heat generation with unique design approaches to control magnetism. Finally, we discuss highly effective biomedical application studies such as dual-mode magnetic hyperthermia, magnetothermally triggered drug delivery, and the magnetothermal control of cellular activities.

中文翻译：

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纳米粒子磁热能力的最新进展：从设计原理到生物医学应用

摘要 磁性纳米粒子 (MNP) 介导的加热系统已成为一种有效的策略，可以以时空控制的方式精细控制从热疗到细胞信号传导的生物系统。为了获得令人满意的性能，已经开发出先进的设计概念来定制直接影响纳米颗粒加热性能的磁性。在这篇综述中，我们关注磁性工程纳米粒子的最新进展。首先讨论磁加热机制的基本原理和相关的关键磁参数，为设计具有更高加热效率的 MNP 提供指导性指导。然后，我们重点介绍了 MNP 在优化发热方面的最新进展，并采用独特的设计方法来控制磁性。最后，