Retinopathy and nephropathy are life-threatening diabetic complications that decrease patient quality of life. Although the mechanisms underlying these conditions have been extensively studied, they remain unknown. Recent reports have demonstrated the presence of sodium glucose cotransporter 2 (SGLT2) in retinal pericytes and mesangial cells. Hyperglycemia results in functional and morphological changes in these cells, but these effects are attenuated by phlorizin, a nonselective SGLT inhibitor. Based on these findings, we hypothesized that SGLT2 plays a pivotal role in the development of diabetic nephropathy and retinopathy and that SGLT2 inhibitors may directly protect against these complications.

中文翻译：

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肾小球系膜细胞和视网膜周细胞中的葡萄糖钠转运蛋白2及其对糖尿病肾病和视网膜病的影响

视网膜病和肾病是威胁生命的糖尿病并发症，会降低患者的生活质量。尽管已经深入研究了这些条件的潜在机制，但它们仍是未知的。最近的报道表明，视网膜周细胞和系膜细胞中存在钠葡萄糖共转运蛋白2（SGLT2）。高血糖会导致这些细胞的功能和形态发生变化，但非选择性SGLT抑制剂Phlorizin减弱了这些作用。基于这些发现，我们假设SGLT2在糖尿病性肾病和视网膜病的发展中起着关键作用，并且SGLT2抑制剂可以直接预防这些并发症。