For the first time a general overview of approaches to the synthesis of natural product analogues is presented. This reflects a process of evolution of natural product synthesis which has accelerated in the years since the implementation of diversity-oriented synthesis, which has emerged in parallel with collective synthesis, diverted total synthesis and the preparation of truncated natural products optimised for biological activity. A method involving computational assessment for the validation of core-modified natural product analogues is discussed.

中文翻译：

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天然产物类似物：迈向以类似物为中心的合成蓝图

首次提出了天然产物类似物合成方法的概述。这反映了自从实施面向多样性的合成以来，天然产物合成的进化过程加速了，该过程与集体合成，转移总合成以及为生物活性优化的截短天然产物的制备同时出现。讨论了一种涉及计算评估的方法，用于验证核心修饰的天然产物类似物。