Diagnosing bone metastases with traditional anatomic modalities, such as MRI and CT, is limited by sensitivity, and conventional bone radiotracers are only indirect markers of cancer activity. Fortunately, molecular imaging is uniquely capable of providing radiotracers such as fluciclovine and radiolabeled choline, that actually target tumors in the bone. The merits of research in imaging osseous metastases in animal models using these radiotracers and the implications for future clinical translation are discussed.

中文翻译：

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氟氯氯乙烯PET在分子转移中的分子追踪研究

用传统的解剖学方式（例如MRI和CT）诊断骨转移受到敏感性的限制，而传统的骨放射性示踪剂只是癌症活动的间接标志物。幸运的是，分子成像独特地能够提供放射性示踪剂，例如flucloclovine和放射性标记的胆碱，它们实际上靶向骨骼中的肿瘤。讨论了使用这些放射性示踪剂对动物模型中骨转移进行成像的优点，以及对未来临床翻译的意义。