Two-dimensional (2D) zirconium-based metal–organic framework nanosheets embedded with Au nanoclusters (denoted as 2D AuNCs@521-MOF) were prepared via a one-pot method under mild conditions. The optimized 2D AuNCs@521-MOF nanosheets not only possessed high specific surface area, physicochemical stability, and good electrochemical activity but also exhibited strong bioaffinity toward biomolecule-bearing phosphate groups. Consequently, a large amount of cocaine aptamer strands can be immobilized onto the substrate modified by 2D AuNCs@521-MOF nanosheet, further leading to the formation of a constructed biosensitive platform, which can be used to successfully detect cocaine through the specific binding interactions between cocaine and aptamer strands. The results demonstrated that the 2D AuNCs@521-MOF-based aptasensor had high sensitivity for detecting cocaine within the broad concentration range of 0.001–1.0 ng·mL^–1 and the low limit of detection of 1.29 pM (0.44 pg·mL^–1) and 2.22 pM (0.75 pg·mL^–1) as determined by electrochemical impedance spectroscopy and differential pulse voltammetry, respectively. As expected, with the advantages of high selectivity, repeatability, stability, and simple operation, this new strategy is believed to exhibit great potential for simple and convenient detection of cocaine.

中文翻译：

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二维锆基金属-有机骨架纳米片复合材料嵌入Au纳米团簇：一种用于检测可卡因的高灵敏度电化学适应传感器。

通过一锅法在温和条件下制备嵌入金纳米团簇（表示为二维AuNCs @ 521-MOF）的二维（2D）锆基金属-有机骨架纳米片。优化的二维AuNCs @ 521-MOF纳米片不仅具有较高的比表面积，理化稳定性和良好的电化学活性，而且还具有很强的对带有生物分子的磷酸酯基团的亲和力。因此，大量可卡因适体链可被固定在经2D AuNCs @ 521-MOF纳米片修饰的底物上，进一步导致构建的生物敏感平台的形成，可用于通过可卡因之间的特异性结合相互作用成功检测可卡因。可卡因和适体链。^–1和1.29 pM的检测下限分别由电化学阻抗谱和差分脉冲伏安法测定，分别为1.29 pM（0.44 pg·mL ^–1）和2.22 pM（0.75 pg·mL ^–1）。如所期望的，具有高选择性，可重复性，稳定性和简单操作的优点，据信这种新策略在简单和方便地检测可卡因方面显示出巨大潜力。