Yuta Kochi and colleagues perform expression quantitative trait loci (eQTL) analysis on five subsets of immune cells individually sorted from blood from 105 individuals. They develop an integrated analysis pipeline of expression and epigenomic data along with gene association to identify cell-specific candidate causal genes and apply this to rheumatoid arthritis.

中文翻译：

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细胞特异性途径的多基因负担是类风湿关节炎的风险

Yuta Kochi及其同事对从105个人的血液中分选出来的5个免疫细胞亚群进行了表达定量性状基因座（eQTL）分析。他们开发了表达和表观基因组数据以及基因关联的综合分析流水线，以鉴定细胞特异性候选病因基因并将其应用于类风湿关节炎。