Intrahepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC) are clinically disparate primary liver cancers with etiological and biological heterogeneity. We identified common molecular subtypes linked to similar prognosis among 199 Thai ICC and HCC patients through systems integration of genomics, transcriptomics, and metabolomics. While ICC and HCC share recurrently mutated genes, including TP53, ARID1A, and ARID2, mitotic checkpoint anomalies distinguish the C1 subtype with key drivers PLK1 and ECT2, whereas the C2 subtype is linked to obesity, T cell infiltration, and bile acid metabolism. These molecular subtypes are found in 582 Asian, but less so in 265 Caucasian patients. Thus, Asian ICC and HCC, while clinically treated as separate entities, share common molecular subtypes with similar actionable drivers to improve precision therapy.

中文翻译：

---

亚洲肝细胞癌和胆管癌之间的常见分子亚型。

肝内胆管癌（ICC）和肝细胞癌（HCC）是临床上不同的原发性肝癌，具有病因和生物学异质性。通过基因组学，转录组学和代谢组学的系统集成，我们确定了199名泰国ICC和HCC患者中与相似预后相关的常见分子亚型。虽然ICC和HCC共享包括TP53，ARID1A和ARID2在内的经常突变的基因，但有丝分裂检查点异常将C1亚型与关键驱动因素PLK1和ECT2区分开，而C2亚型与肥胖症，T细胞浸润和胆汁酸代谢有关。这些分子亚型在582名亚洲人中发现，但在265名白人患者中则较少。因此，尽管亚洲ICC和HCC在临床上被视为独立实体，