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Commercial Applications for Enzyme-Mediated Protein Conjugation: New Developments in Enzymatic Processes to Deliver Functionalized Proteins on the Commercial Scale
Chemical Reviews ( IF 51.4 ) Pub Date : 2017-06-19 00:00:00 , DOI: 10.1021/acs.chemrev.6b00832 Erika M. Milczek 1
Chemical Reviews ( IF 51.4 ) Pub Date : 2017-06-19 00:00:00 , DOI: 10.1021/acs.chemrev.6b00832 Erika M. Milczek 1
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The field of protein conjugation most commonly refers to the chemical, enzymatic, or chemoenzymatic formation of new covalent bonds between two polypeptides, or between a single polypeptide and a new molecule (polymer, small molecule, nucleic acid, carbohydrate, etc.). Due to the modest selectivity of chemical methods for protein conjugation, there are increased efforts to develop biocatalysts that confer regioselectivity for site-specific modification, thereby complementing the existing toolbox of chemical conjugation strategies. This review summarizes key advances in the use of enzymes to functionalize proteins with commercial relevance. The examples put forth have demonstrated value at the industrial level or show promising industrial potential in the laboratory.
中文翻译：
酶介导的蛋白质偶联的商业应用：以商业规模提供功能化蛋白质的酶促工艺的新进展
蛋白质缀合领域最通常是指两个多肽之间，或单个多肽与新分子（聚合物，小分子，核酸，碳水化合物等）之间新的共价键的化学，酶促或化学酶促形成。由于蛋白质缀合的化学方法的选择性中等，因此人们加大了开发生物催化剂的力度，这些催化剂赋予了针对位点特异性修饰的区域选择性，从而补充了现有的化学缀合策略工具箱。这篇综述总结了利用酶功能化具有商业意义的蛋白质的关键进展。所举的例子已经在工业水平上证明了价值，或者在实验室中显示了有希望的工业潜力。
更新日期：2017-06-19
中文翻译：
酶介导的蛋白质偶联的商业应用：以商业规模提供功能化蛋白质的酶促工艺的新进展
蛋白质缀合领域最通常是指两个多肽之间，或单个多肽与新分子（聚合物，小分子，核酸，碳水化合物等）之间新的共价键的化学，酶促或化学酶促形成。由于蛋白质缀合的化学方法的选择性中等，因此人们加大了开发生物催化剂的力度，这些催化剂赋予了针对位点特异性修饰的区域选择性，从而补充了现有的化学缀合策略工具箱。这篇综述总结了利用酶功能化具有商业意义的蛋白质的关键进展。所举的例子已经在工业水平上证明了价值，或者在实验室中显示了有希望的工业潜力。
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