当前位置: X-MOL 学术ACS Sens. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Plasmon-Based Colorimetric Nanosensors for Ultrasensitive Molecular Diagnostics
ACS Sensors ( IF 8.2 ) Pub Date : 2017-06-16 00:00:00 , DOI: 10.1021/acssensors.7b00282
Longhua Tang 1 , Jinghong Li 2
Affiliation  

Colorimetric detection of target analytes with high specificity and sensitivity is of fundamental importance to clinical and personalized point-of-care diagnostics. Because of their extraordinary optical properties, plasmonic nanomaterials have been introduced into colorimetric sensing systems, which provide significantly improved sensitivity in various biosensing applications. Here we review the recent progress on these plasmonic nanoparticles-based colorimetric nanosensors for ultrasensitive molecular diagnostics. According to their different colorimetric signal generation mechanisms, these plasmonic nanosensors are classified into two categories: (1) interparticle distance-dependent colorimetric assay based on target-induced forming cross-linking assembly/aggregate of plasmonic nanoparticles; and (2) size/morphology-dependent colorimetric assay by target-controlled growth/etching of the plasmonic nanoparticles. The sensing fundamentals and cutting-edge applications will be provided for each of them, particularly focusing on signal generation and/or amplification mechanisms that realize ultrasensitive molecular detection. Finally, we also discuss the challenge and give our future perspective in this emerging field.

中文翻译:

基于等离子的比色纳米传感器用于超灵敏的分子诊断

比色检测具有高特异性和灵敏度的目标分析物对于临床和个性化即时诊断至关重要。由于其非凡的光学性能,等离激元纳米材料已被引入比色传感系统,该系统在各种生物传感应用中提供了显着提高的灵敏度。在这里,我们回顾了这些基于等离激元纳米粒子的比色纳米传感器在超灵敏分子诊断中的最新进展。根据它们的比色信号产生机理的不同,这些等离激元纳米传感器可分为两类:(1)基于目标诱导的等离激元纳米粒子的形成交联组装/聚集的粒子间距离相关比色测定;(2)通过靶控制的等离子体纳米颗粒的生长/蚀刻来进行尺寸/形态依赖的比色测定。将为它们中的每一个提供传感基础和前沿应用程序,尤其着重于实现超灵敏分子检测的信号生成和/或放大机制。最后,我们还讨论了这一挑战,并给出了在这个新兴领域的未来展望。
更新日期:2017-06-28
down
wechat
bug