Conflicting data exist on the requirement for wild-type MLL1 in MLL-rearranged leukemia. In this issue ofCancer Cell, Chen et al. describe complementary approaches demonstrating that MLL1 is dispensable for MLL-fusion-mediated leukemogenesis. They also observe an unexpected role for MLL2 in MLL-rearranged leukemia cells and identify potential therapeutic targets.

中文翻译：

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MLL同源物在MLL重排的白血病中的悖论效应

关于在MLL重排的白血病中对野生型MLL1的需求存在矛盾的数据。在本期《癌细胞》中，Chen等人。描述了证明MLL1对于MLL融合介导的白血病发生是可有可无的补充方法。他们还观察到MLL2在MLL重排的白血病细胞中具有意想不到的作用，并确定了潜在的治疗靶标。