Glycosylation alterations are involved in several steps of human cancer pathogenesis. In this issue ofCancer Cell, Agrawal et al. identified the glycosyltransferase FUT8 as a previously unrecognized mediator of melanoma metastasis, establishing core fucosylation as a potential therapeutic target for prevention and treatment of metastatic tumors.

中文翻译：

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癌症中异常糖基化：控制转移的新型分子机制。

糖基化改变涉及人类癌症发病机理的几个步骤。在本期《癌细胞》中，Agrawal等人。确认糖基转移酶FUT8是以前无法识别的黑色素瘤转移介质，确立了核心岩藻糖基化作为预防和治疗转移性肿瘤的潜在治疗靶点。