DNA Origami: Scaffolds for Creating Higher Order Structures,Chemical Reviews

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DNA Origami: Scaffolds for Creating Higher Order Structures
Chemical Reviews ( IF 51.4 ) Pub Date : 2017-06-12 00:00:00 , DOI: 10.1021/acs.chemrev.6b00825
Fan Hong ₁ , Fei Zhang ₁ , Yan Liu ₁ , Hao Yan ₁

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DNA has become one of the most extensively used molecular building blocks for engineering self-assembling materials. DNA origami is a technique that uses hundreds of short DNA oligonucleotides, called staple strands, to fold a long single-stranded DNA, which is called a scaffold strand, into various designer nanoscale architectures. DNA origami has dramatically improved the complexity and scalability of DNA nanostructures. Due to its high degree of customization and spatial addressability, DNA origami provides a versatile platform with which to engineer nanoscale structures and devices that can sense, compute, and actuate. These capabilities open up opportunities for a broad range of applications in chemistry, biology, physics, material science, and computer science that have often required programmed spatial control of molecules and atoms in three-dimensional (3D) space. This review provides a comprehensive survey of recent developments in DNA origami structure, design, assembly, and directed self-assembly, as well as its broad applications.

中文翻译：

DNA折纸：用于创建更高阶结构的支架

DNA已成为工程自组装材料中使用最广泛的分子构建基块之一。DNA折纸是一种使用数百种短的DNA寡核苷酸（称为短链）将长的单链DNA（称为支架链）折叠成各种设计器纳米级结构的技术。DNA折纸极大地提高了DNA纳米结构的复杂性和可扩展性。由于其高度的自定义性和空间可寻址性，DNA折纸提供了一个通用平台，可用来设计可感测，计算和激活的纳米级结构和设备。这些功能为化学，生物学，物理学，材料科学，和计算机科学，通常需要对三维（3D）空间中的分子和原子进行程序化的空间控制。本文对DNA折纸的结构，设计，组装和定向自组装及其广泛应用进行了全面的综述。

更新日期：2017-06-12

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