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Dynamic Supramolecular Hydrogels: Regulating Hydrogel Properties through Self-Complementary Quadruple Hydrogen Bonds and Thermo-Switch
ACS Macro Letters ( IF 5.1 ) Pub Date : 2017-06-12 00:00:00 , DOI: 10.1021/acsmacrolett.7b00275 Guangzhao Zhang 1 , Yunhua Chen 2 , Yonghong Deng 3 , To Ngai 4 , Chaoyang Wang 1
ACS Macro Letters ( IF 5.1 ) Pub Date : 2017-06-12 00:00:00 , DOI: 10.1021/acsmacrolett.7b00275 Guangzhao Zhang 1 , Yunhua Chen 2 , Yonghong Deng 3 , To Ngai 4 , Chaoyang Wang 1
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We report here a supramolecular hydrogel displaying a wide array of dynamic desirable properties. The key is using an ABA triblock copolymer containing a central poly(ethylene oxide) block and terminal poly(N-isopropylacrylamide) (PNIPAm) block with ureido pyrimidinone (UPy) moieties randomly incorporated. Rapid hydrogelation is triggered upon increasing temperature above the lower critical solution temperature (LCST) of the supramolecular copolymer, where PNIPAm segments dehydrate and assemble into micelles, which subsequently provide hydrophobic microenvironments promoting UPy dimerization to grab polymer chains, thus forming hydrogen-bonded cross-linking points. The supramolecular hydrogels demonstrate fascinating shear-thinning, self-healable, thermo-reversible, and injectable properties, which allow withstanding repeated deformations and 3D construction of complex objects. Mesenchymal stem cells mixed with the hydrogel and injected through needles remain highly viable (>90%) during the encapsulation and delivery process. With these attractive dynamic physical properties, the supramolecular hydrogel holds great promise to support cell or drug therapies.
中文翻译：
动态超分子水凝胶：通过自互补四重氢键和热开关调节水凝胶性能
我们在这里报告了一种超分子水凝胶，显示出广泛的动态理想特性。关键是使用含有中心聚（环氧乙烷）嵌段和末端聚（N-异丙基丙烯酰胺) (PNIPAm) 嵌段与脲基嘧啶酮 (UPy) 部分随机结合。当温度升高到超分子共聚物的较低临界溶解温度 (LCST) 以上时，会触发快速水凝胶化，其中 PNIPAm 链段脱水并组装成胶束，随后提供疏水微环境，促进 UPy 二聚化以抓住聚合物链，从而形成氢键交联链接点。超分子水凝胶表现出迷人的剪切稀化、自愈、热可逆和可注射特性，可以承受复杂物体的重复变形和 3D 构造。与水凝胶混合并通过针头注射的间充质干细胞在封装和递送过程中保持高度存活 (>90%)。
更新日期：2017-06-12
中文翻译：
动态超分子水凝胶：通过自互补四重氢键和热开关调节水凝胶性能
我们在这里报告了一种超分子水凝胶，显示出广泛的动态理想特性。关键是使用含有中心聚（环氧乙烷）嵌段和末端聚（N-异丙基丙烯酰胺) (PNIPAm) 嵌段与脲基嘧啶酮 (UPy) 部分随机结合。当温度升高到超分子共聚物的较低临界溶解温度 (LCST) 以上时，会触发快速水凝胶化，其中 PNIPAm 链段脱水并组装成胶束，随后提供疏水微环境，促进 UPy 二聚化以抓住聚合物链，从而形成氢键交联链接点。超分子水凝胶表现出迷人的剪切稀化、自愈、热可逆和可注射特性，可以承受复杂物体的重复变形和 3D 构造。与水凝胶混合并通过针头注射的间充质干细胞在封装和递送过程中保持高度存活 (>90%)。
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