Iodide-Selective Synthetic Ion Channels Based on Shape-Persistent Organic Cages,Journal of the American Chemical Society

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Iodide-Selective Synthetic Ion Channels Based on Shape-Persistent Organic Cages
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2017-05-24 00:00:00 , DOI: 10.1021/jacs.7b02708
Bahiru Punja Benke ₁ , Pulakesh Aich ₁ , Younghoon Kim ₂ , Kyung Lock Kim ₁ , Md Rumum Rohman ₁ , Soonsang Hong _{1,

2} , In-Chul Hwang ₁ , Eun Hui Lee ₃ , Joon Ho Roh ₁ , Kimoon Kim _{1,

2}

Affiliation

We report here a synthetic ion channel developed from a shape-persistent porphyrin-based covalent organic cage. The cage was synthesized by employing a synthetically economical dynamic covalent chemistry (DCC) approach. The organic cage selectively transports biologically relevant iodide ions over other inorganic anions by a dehydration-driven, channel mechanism as evidenced by vesicle-based fluorescence assays and planar lipid bilayer-based single channel recordings. Furthermore, the organic cage appears to facilitate iodide transport across the membrane of a living cell, suggesting that the cage could be useful as a biological tool that may replace defective iodide channels in living systems.

中文翻译：

基于形状持久性有机笼的碘离子选择性合成离子通道

我们在这里报告从形状持久的基于卟啉的共价有机笼子发展出的合成离子通道。该笼子是采用合成经济的动态共价化学（DCC）方法合成的。通过基于囊泡的荧光测定法和基于平面脂质双层的单通道记录所证明的脱水驱动的通道机理，有机笼选择性地将生物学上相关的碘离子转运到其他无机阴离子上。此外，有机笼子似乎有助于碘化物跨过活细胞膜的运输，这表明笼子可用作生物工具，可以代替生物系统中有缺陷的碘化物通道。

更新日期：2017-05-27

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