Accelerating chemical reactions by molecular sledding,Chemical Communications

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Accelerating chemical reactions by molecular sledding
Chemical Communications ( IF 4.3 ) Pub Date : 2017-05-26 00:00:00 , DOI: 10.1039/c7cc02500a
Lei Zhang _{1,

2,

3,

4,

5} , Lifei Zheng _{1,

2,

3} , Zhuojun Meng _{1,

2,

3} , Konstantin Balinin _{1,

2,

3} , Mark Loznik _{1,

2,

3} , Andreas Herrmann _{1,

2,

3}

Affiliation

The speed-up of covalent bond formation was achieved between a sulfhydryl group and a 2-bromopropionic acid derivative by utilizing sliding peptide-modified substrates. Moreover, a new type of DNA cleaving reagent was developed, consisting of pVIc covalently coupled to verteporfin. This peptide–porphyrin conjugate allowed targeting of DNA and resulted in increased photodegradation of double-stranded nucleic acids.

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