Silver-mediated radical 5-exo-dig cyclization of 2-alkynylbenzonitriles: synthesis of phosphinylated 1-indenones,Chemical Communications

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Silver-mediated radical 5-exo-dig cyclization of 2-alkynylbenzonitriles: synthesis of phosphinylated 1-indenones
Chemical Communications ( IF 4.3 ) Pub Date : 2017-05-19 00:00:00 , DOI: 10.1039/c7cc01666b
Xiao-Tong Zhu _{1,

2,

3,

4,

5} , Qi Zhao _{1,

2,

3,

4} , Feng Liu _{1,

2,

3,

4} , Ai-Fang Wang _{1,

2,

3,

4} , Pei-Jun Cai _{3,

4,

5,

6} , Wen-Juan Hao _{1,

2,

3,

4} , Shu-Jiang Tu _{1,

2,

3,

4} , Bo Jiang _{1,

2,

3,

4}

Affiliation

A new silver-mediated 5-exo-dig cyclization of 2-alkynylbenzonitriles with disubstituted phosphine oxide and H₂O has been developed. The reaction enables multiple bond-forming events including C–P, C–C and C–O bonds under atmospheric conditions, leading to the concise and direct formation of 28 examples of phosphorus-containing 1-indenones with generally good yields.

中文翻译：

银介导的2-炔基苄腈的自由基5-外切-环化反应：次膦酸酯化的1-茚三酮的合成

已经开发了一种新的银介导的2-炔基苄腈与双取代的氧化膦和H ₂ O的5 -exo-dig环化反应。该反应可在大气条件下形成包括C–P，CC–C和C–O键在内的多种键形成事件，从而导致简洁，直接地形成28个含磷的1-茚满实例，收率通常很高。

更新日期：2017-05-27

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