Sugar-Breathing Glycopolymersomes for Regulating Glucose Level,Journal of the American Chemical Society

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Sugar-Breathing Glycopolymersomes for Regulating Glucose Level
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2017-05-16 00:00:00 , DOI: 10.1021/jacs.7b03219
Yufen Xiao ₁ , Hui Sun ₁ , Jianzhong Du _{1,

2}

Affiliation

Diabetes mellitus is a chronic, life-threatening illness that affects people of every age and ethnicity. It is a long-term pain for those who are affected and must regulate their blood glucose level by frequent subcutaneous injection of insulin every day. Herein, we propose a noninsulin and antidiabetic drug-free strategy for regulating blood glucose level by a nanosized “sugar sponge” which is a lectin-bound glycopolymersome capable of regulating glucose due to the dynamic recognition between the lectin and different carbohydrates. The glycopolymersome is self-assembled from poly(ethylene oxide)-block-poly[(7-(2-methacryloyloxyethoxy)-4-methylcoumarin)-stat-2-(diethylamino)ethyl methacrylate-stat-(α-d-glucopyranosyl)ethyl methacrylate] [PEO-b-P(CMA-stat-DEA-stat-GEMA)]. The lectin bound in the glycopolymersome has different affinity for the glucose in the blood and the glucosyl group in the glycopolymersome. Therefore, this sugar sponge functions as a glucose storage unit by dynamic sugar replacement: The lectin in the sugar sponge will bind and store the glucose from its surrounding solution when the glucose concentration is too high and will release the glucose when the glucose concentration is too low. In vitro, this sugar-breathing behavior is characterized by a remarkable size change of the sugar sponge due to the swelling/shrinkage at high/low glucose levels, which can be used for blood sugar monitoring. In vivo, this sugar sponge showed an excellent antidiabetic effect for type I diabetic mice within 2 days upon one dose, which is much longer than traditional long-acting insulin. Overall, this concept of “controlling sugar levels with sugar” opens new avenues for regulating the blood glucose level without the involvement of insulin or other antidiabetic drugs.

中文翻译：

调糖糖调节糖水平

糖尿病是一种威胁生命的慢性疾病，会影响各个年龄段和不同种族的人。对于受影响的人来说，这是一种长期的痛苦，必须每天通过每天皮下注射胰岛素来调节血糖水平。在本文中，我们提出了一种非胰岛素和抗糖尿病的无药策略，可通过纳米级“糖海绵”调节血糖水平，该糖海绵是一种由于凝集素与不同碳水化合物之间的动态识别而能够调节葡萄糖的凝集素结合型糖聚合物。所述glycopolymersome是自组装的由聚（环氧乙烷） -嵌段-聚[（7-（2-甲基丙烯酰氧基）-4-甲基香豆素） - STAT -2-（二乙氨基）乙基甲基丙烯酸酯STAT - （α- d-吡喃葡糖基）甲基丙烯酸乙酯] [PEO- b -P（CMA- stat -DEA- stat-GEMA）]。结合在糖多聚体中的凝集素对血液中的葡萄糖和糖多聚体中的葡糖基具有不同的亲和力。因此，这种糖海绵通过动态糖替代而充当葡萄糖储存单元：糖海绵中的凝集素会在葡萄糖浓度过高时结合并从周围溶液中储存葡萄糖，而在葡萄糖浓度过高时会释放出葡萄糖。低的。在体外，这种糖呼吸行为的特征是由于在高/低葡萄糖水平下的溶胀/收缩，糖海绵的尺寸发生了显着变化，可用于血糖监测。在体内，这种糖海绵在服用一剂后的2天内对I型糖尿病小鼠显示出出色的抗糖尿病作用，比传统的长效胰岛素长得多。全面的，

更新日期：2017-05-27

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