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A deciduous directing group approach for the addition of aryl and vinyl nucleophiles to maleimides
Chemical Communications ( IF 4.3 ) Pub Date : 2017-05-15 00:00:00 , DOI: 10.1039/c7cc02392h
Kiran R. Bettadapur 1, 2, 3, 4 , Veeranjaneyulu Lanke 1, 2, 3, 4 , Kandikere Ramaiah Prabhu 1, 2, 3, 4
Affiliation  

A Rh(III)-catalyzed C–H activation followed by conjugate addition to maleimides, using carboxylic acid as a traceless/deciduous directing group, to formally furnish a Csp2–Csp3 bond is presented. For the first time, derivatives of acrylic acid have been shown as surrogates for the unstable and expensive alkenyl boronic acids.

中文翻译:

将芳基和乙烯基亲核试剂添加到马来酰亚胺中的落叶指导基团方法

提出了Rh(III)催化的C–H活化,然后使用羧酸作为无痕/落叶导向基团,共轭加成至马来酰亚胺,以正式提供C sp 2 –C sp 3键。丙烯酸衍生物首次被证明是不稳定和昂贵的烯基硼酸的替代物。
更新日期:2017-05-26
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