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Palladium-catalyzed oxidative carbonylation of N-aryl enamino esters with CO and alcohols: synthesis of N-aryl aminomethylenemalonates
Chemical Communications ( IF 4.3 ) Pub Date : 2017-05-10 00:00:00 , DOI: 10.1039/c7cc02852k
Ming Chen 1, 2, 3, 4, 5 , Le Yu 1, 2, 3, 4, 5 , Zhi-Hui Ren 1, 2, 3, 4, 5 , Yao-Yu Wang 1, 2, 3, 4, 5 , Zheng-Hui Guan 1, 2, 3, 4, 5
Affiliation  

A novel palladium-catalyzed regioselective oxidative carbonylation of tri-substituted alkenes with CO and alcohols for the synthesis of α,β-unsaturated esters has been developed. Experimental studies and DFT calculations suggested that the reaction proceeded through alkoxylation of the palladium(II) catalyst, CO and C[double bond, length as m-dash]C double bond migratory insertion, β-(N)H elimination and tautomerization cascade steps. The reaction tolerates a wide range of groups and produces valuable aminomethylenemalonates in high yields.

中文翻译:

N-芳基烯氨基酯与CO和醇的钯催化氧化羰基化:N-芳基氨基亚甲基丙二酸酯的合成

已经开发了新颖的钯催化的三取代烯烃与CO和醇的区域选择性氧化羰基化反应,用于合成α,β-不饱和酯。实验研究和DFT计算表明,该反应通过钯(II)催化剂的烷氧基化,CO和C [双键,长度为m-破折号]C双键迁移插入,β-(N)H消除和互变异构级联步骤进行。该反应可耐受各种基团,并以高收率产生有价值的氨基亚甲基丙二酸酯。
更新日期:2017-05-25
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