5-Benzylidene-4-oxazolidinones potently inhibit biofilm formation in Methicillin-resistant Staphylococcus aureus,Chemical Communications

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5-Benzylidene-4-oxazolidinones potently inhibit biofilm formation in Methicillin-resistant Staphylococcus aureus
Chemical Communications ( IF 4.3 ) Pub Date : 2017-05-16 00:00:00 , DOI: 10.1039/c7cc03626d
Grant A. Edwards _{1,

2,

3,

4,

5} , Nataliia V. Shymanska _{1,

2,

3,

4} , Joshua G. Pierce _{1,

2,

3,

4,

5}

Affiliation

Investigation into the biological function of 5-benzylidene-4-oxazolidinones revealed dose-dependent inhibition of biofilm formation in Methicillin-resistant S. aureus (MRSA). This structurally unusual class of small molecules inhibit up to 89% of biofilm formation with IC₅₀ values as low as 0.78 μM, and disperse pre-formed biofilms with IC₅₀ values as low as 4.7 μM. Together, these results suggest that 4-oxazolidinones represent new chemotypes to enable the study of bacterial biofilms with small molecule chemical probes.

中文翻译：

5-苄叉基-4-恶唑烷酮类有效抑制耐甲氧西林金黄色葡萄球菌的生物膜形成

对5-亚苄基-4-恶唑烷酮的生物学功能的研究表明，对耐甲氧西林的金黄色葡萄球菌（MRSA）的生物膜形成具有剂量依赖性的抑制作用。这种结构上不寻常的小分子类别抑制了高达89％的生物膜形成，其IC ₅₀值低至0.78μM，并且分散了预先形成的生物膜，其IC ₅₀值低至4.7μM。总之，这些结果表明4-恶唑烷酮代表了新的化学型，从而能够使用小分子化学探针研究细菌生物膜。

更新日期：2017-05-24

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