Synthesis of biotin-labelled core glycans of GPI anchors and their application in the study of GPI interaction with pore-forming bacterial toxins,Chemical Communications

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Synthesis of biotin-labelled core glycans of GPI anchors and their application in the study of GPI interaction with pore-forming bacterial toxins
Chemical Communications ( IF 4.3 ) Pub Date : 2017-05-15 00:00:00 , DOI: 10.1039/c7cc03056h
Jian Gao _{1,

2,

3,

4} , Zhifang Zhou _{1,

2,

3,

4} , Jiatong Guo _{1,

1,

2,

3,

4} , Zhongwu Guo _{1,

1,

2,

3,

4}

Affiliation

A convergent strategy was developed for the first-time synthesis of biotin-labeled GPI core glycans. These GPI conjugates are useful for various biological studies showcased by their application in the scrutiny of pore-forming bacterial toxin–GPI interaction, revealing that the phosphate group at the GPI inositol 1-O-position had a significant impact on GPI–toxin binding.

中文翻译：

GPI锚蛋白的生物素标记核心聚糖的合成及其在GPI与成孔细菌毒素相互作用研究中的应用

为首次合成生物素标记的GPI核心聚糖开发了一种融合策略。这些GPI共轭物可用于各种生物学研究，这些研究通过检查细孔形成细菌毒素与GPI的相互作用而显示出来，揭示了GPI肌醇1- O位的磷酸基团对GPI与毒素的结合有重要影响。

更新日期：2017-05-24

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