Nitric Oxide Donor-Based Cancer Therapy: Advances and Prospects,Journal of Medicinal Chemistry

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Nitric Oxide Donor-Based Cancer Therapy: Advances and Prospects
Journal of Medicinal Chemistry ( IF 6.8 ) Pub Date : 2017-05-15 00:00:00 , DOI: 10.1021/acs.jmedchem.6b01672
Zhangjian Huang ₁ , Junjie Fu ₂ , Yihua Zhang ₁

Affiliation

The increasing understanding of the role of nitric oxide (NO) in cancer biology has generated significant progress in the use of NO donor-based therapy to fight cancer. These advances strongly suggest the potential adoption of NO donor-based therapy in clinical practice, and this has been supported by several clinical studies in the past decade. In this review, we first highlight several types of important NO donors, including recently developed NO donors bearing a dinitroazetidine skeleton, represented by RRx-001, with potential utility in cancer therapy. Special emphasis is then given to the combination of NO donor(s) with other therapies to achieve synergy and to the hybridization of NO donor(s) with an anticancer drug/agent/fragment to enhance the activity or specificity or to reduce toxicity. In addition, we briefly describe inducible NO synthase gene therapy and nanotechnology, which have recently entered the field of NO donor therapy.

中文翻译：

一氧化氮供体为基础的癌症治疗：进展和前景。

对一氧化氮（NO）在癌症生物学中的作用的日益了解，已在使用基于NO供体的疗法抗击癌症中取得了重大进展。这些进展有力地表明了基于NO供体的疗法在临床实践中的潜在应用，并且在过去十年中的一些临床研究中对此给予了支持。在这篇综述中，我们首先重点介绍几种重要的NO供体类型，包括最近开发的带有二硝基氮杂环丁烷骨架的NO供体，以RRx-001表示，在癌症治疗中具有潜在的实用性。然后特别强调NO供体与其他疗法的组合以实现协同作用，以及NO供体与抗癌药物/试剂/片段的杂交以增强活性或特异性或降低毒性。此外，

更新日期：2017-06-28

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