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Transition-Metal-Catalyzed Utilization of Methanol as a C1 Source in Organic Synthesis
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2017-04-25 06:25:45 , DOI: 10.1002/anie.201612520
Kishore Natte 1 , Helfried Neumann 1 , Matthias Beller 1 , Rajenahally V. Jagadeesh 1
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Methanol is used as a common solvent, cost-effective reagent, and sustainable feedstock for value-added chemicals, pharmaceuticals, and materials. Among the various applications, the utilization of methanol as a C1 source for the formation of carbon–carbon, carbon–nitrogen, and carbon–oxygen bonds continues to be important in organic synthesis and drug discovery. In particular, the synthesis of C-, N-, and O-methylated products is of central interest because these motifs are found in a large number of natural products as well as fine and bulk chemicals. In this Minireview, we summarize the utilization of methanol as a C1 source in methylation, methoxylation, formylation, methoxycarbonylation, and oxidative methyl ester formation reactions.

中文翻译:

过渡金属催化的甲醇作为有机合成中的C1来源

甲醇用作增值化学品,药品和材料的常用溶剂,具有成本效益的试剂和可持续原料。在各种应用中,利用甲醇作为C 1源来形成碳-碳,碳-氮和碳-氧键在有机合成和药物开发中仍然很重要。特别地,C-,N-和O-甲基化产物的合成是主要关注的问题,因为这些基序存在于大量天然产物以及精细化学品和大宗化学品中。在此Minireview中,我们总结了在甲基化,甲氧基化,甲酰化,甲氧基羰基化和氧化甲酯形成反应中利用甲醇作为C 1来源。
更新日期:2017-05-24
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