Transition-Metal-Catalyzed Utilization of Methanol as a C1 Source in Organic Synthesis,Angewandte Chemie International Edition

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Transition-Metal-Catalyzed Utilization of Methanol as a C1 Source in Organic Synthesis
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2017-04-25 06:25:45 , DOI: 10.1002/anie.201612520
Kishore Natte ₁ , Helfried Neumann ₁ , Matthias Beller ₁ , Rajenahally V. Jagadeesh ₁

Affiliation

Methanol is used as a common solvent, cost-effective reagent, and sustainable feedstock for value-added chemicals, pharmaceuticals, and materials. Among the various applications, the utilization of methanol as a C₁ source for the formation of carbon–carbon, carbon–nitrogen, and carbon–oxygen bonds continues to be important in organic synthesis and drug discovery. In particular, the synthesis of C-, N-, and O-methylated products is of central interest because these motifs are found in a large number of natural products as well as fine and bulk chemicals. In this Minireview, we summarize the utilization of methanol as a C₁ source in methylation, methoxylation, formylation, methoxycarbonylation, and oxidative methyl ester formation reactions.

中文翻译：

过渡金属催化的甲醇作为有机合成中的C1来源

甲醇用作增值化学品，药品和材料的常用溶剂，具有成本效益的试剂和可持续原料。在各种应用中，利用甲醇作为C ₁源来形成碳-碳，碳-氮和碳-氧键在有机合成和药物开发中仍然很重要。特别地，C-，N-和O-甲基化产物的合成是主要关注的问题，因为这些基序存在于大量天然产物以及精细化学品和大宗化学品中。在此Minireview中，我们总结了在甲基化，甲氧基化，甲酰化，甲氧基羰基化和氧化甲酯形成反应中利用甲醇作为C ₁来源。

更新日期：2017-05-24

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