Nitroimidazoles: Molecular Fireworks That Combat a Broad Spectrum of Infectious Diseases,Journal of Medicinal Chemistry

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Nitroimidazoles: Molecular Fireworks That Combat a Broad Spectrum of Infectious Diseases
Journal of Medicinal Chemistry ( IF 6.8 ) Pub Date : 2017-05-02 00:00:00 , DOI: 10.1021/acs.jmedchem.7b00143
Chee Wei Ang ₁ , Angie M. Jarrad ₁ , Matthew A. Cooper ₁ , Mark A. T. Blaskovich ₁

Affiliation

Infectious diseases claim millions of lives every year, but with the advent of drug resistance, therapeutic options to treat infections are inadequate. There is now an urgent need to develop new and effective treatments. Nitroimidazoles are a class of antimicrobial drugs that have remarkable broad spectrum activity against parasites, mycobacteria, and anaerobic Gram-positive and Gram-negative bacteria. While nitroimidazoles were discovered in the 1950s, there has been renewed interest in their therapeutic potential, particularly for the treatment of parasitic infections and tuberculosis. In this review, we summarize different classes of nitroimidazoles that have been described in the literature in the past five years, from approved drugs and clinical candidates to examples undergoing preclinical or early stage development. The relatively “nonspecific” mode of action and resistance mechanisms of nitromidazoles are discussed, and contemporary strategies to facilitate nitroimidazole drug development are highlighted.

中文翻译：

硝基咪唑：与广泛的传染病作斗争的分子烟花

传染病每年夺去数百万人的生命，但是随着耐药性的到来，用于治疗感染的治疗选择不充分。现在迫切需要开发新的有效治疗方法。硝基咪唑是一类抗菌药物，对寄生虫，分枝杆菌和厌氧革兰氏阳性和革兰氏阴性细菌具有显着的广谱活性。硝基咪唑是在1950年代发现的，但人们对其治疗潜力，尤其是对寄生虫感染和肺结核的治疗有了新的兴趣。在这篇综述中，我们总结了过去五年文献中描述的不同类别的硝基咪唑，从批准的药物和临床候选药物到正在进行临床前或早期开发的实例。

更新日期：2017-06-28

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